HIV Integrase (IN-HIV) is a prime target for antiretroviral agents due to its key role in the viral life cycle and the absence of cellular counterparts. A complete understanding of the catalytic mechanism of IN-HIV action is required to combat the increasing incidence of viral resistance against available, marketed drugs.
Atomic force microscopy and surface plasmon resonance studies revealed a specific interaction between the human foamy virus (PFV) IN and its cognate palindromic sequence. These data concur with previous experiments demonstrating a specific IN-HIV activity at the LTR-LTR junction.
@LBPA: Claude Nogues, Olivier Delelis, Eloïse Thierry, Sypabekova Marzhan, Françoise Simon, Fréderic Subra, Hervé Leh, Eric Deprez, Malcolm Buckle